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Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity
Joint Authors
Cicogna, Antonio Carlos
Conde, Sandro José
Olímpio, Regiane Marques Castro
Síbio, Maria Teresa de
Leopoldo, André Soares
Nogueira, Célia Regina
Nascimento, André Ferreira do
Lima-Leopoldo, Ana Paula
Luvizotto, Renata de Azevedo Melo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Aims.
To analyze the influence of hyperthyroidism on the gene expression and serum concentration of leptin, resistin, and adiponectin in obese animals.
Main Methods.
Male Wistar rats were randomly divided into two groups: control (C)—fed with commercial chow ad libitum—and obese (OB)—fed with a hypercaloric diet.
After group characterization, the OB rats continued receiving a hypercaloric diet and were randomized into two groups: obese animals (OB) and obese with 25 μg triiodothyronine (T3)/100 BW (OT).
The T3 dose was administered every day for the last 2 weeks of the study.
After 30 weeks the animals were euthanized.
Samples of blood and adipose tissue were collected for biochemical and hormonal analyses as well as gene expression of leptin, resistin, and adiponectin.
Results.
T3 treatment was effective, increasing fT3 levels and decreasing fT4 and TSH serum concentration.
Administration of T3 promotes weight loss, decreases all fat deposits, and diminishes serum levels of leptin, resistin, and adiponectin by reducing their gene expression.
Conclusions.
Our results suggest that T3 modulate serum and gene expression levels of leptin, resistin, and adiponectin in experimental model of obesity, providing new insights regarding the relationship between T3 and adipokines in obesity.
American Psychological Association (APA)
Luvizotto, Renata de Azevedo Melo& Nascimento, André Ferreira do& Síbio, Maria Teresa de& Olímpio, Regiane Marques Castro& Conde, Sandro José& Lima-Leopoldo, Ana Paula…[et al.]. 2012. Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-497464
Modern Language Association (MLA)
Luvizotto, Renata de Azevedo Melo…[et al.]. Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity. The Scientific World Journal No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-497464
American Medical Association (AMA)
Luvizotto, Renata de Azevedo Melo& Nascimento, André Ferreira do& Síbio, Maria Teresa de& Olímpio, Regiane Marques Castro& Conde, Sandro José& Lima-Leopoldo, Ana Paula…[et al.]. Experimental Hyperthyroidism Decreases Gene Expression and Serum Levels of Adipokines in Obesity. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-497464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497464