Coarse-Grained Simulation of Myosin-V Movement
Joint Authors
Taylor, William R.
Katsimitsoulia, Zoe
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-23
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
We describe the development of a hierarchic modelling method applied to simulating the processive movement of the myosin-V molecular motor protein along an actin filament track.
In the hierarchic model, three different levels of protein structure resolution are represented: secondary structure, domain, and protein, with the level of detail changing according to the degree of interaction among the molecules.
The integrity of the system is maintained using a tree of spatially organised bounding volumes and distance constraints.
Although applied to an actin-myosin system, the hierarchic framework is general enough so that it may easily be adapted to a number of other large biomolecular systems containing in the order of 100 proteins.
We compared the simulation results with biophysical data, and despite the lack of atomic detail in our model, we find good agreement and can even suggest some refinements to the current model of myosin-V motion.
American Psychological Association (APA)
Katsimitsoulia, Zoe& Taylor, William R.. 2012. Coarse-Grained Simulation of Myosin-V Movement. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-497508
Modern Language Association (MLA)
Katsimitsoulia, Zoe& Taylor, William R.. Coarse-Grained Simulation of Myosin-V Movement. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-497508
American Medical Association (AMA)
Katsimitsoulia, Zoe& Taylor, William R.. Coarse-Grained Simulation of Myosin-V Movement. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-497508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497508