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Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer
Joint Authors
Dehm, Scott M.
Kohli, Manish
Qin, Rui
Jimenez, Rafael
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Recent therapeutic advances for managing advanced prostate cancer include the successful targeting of the androgen-AR axis with several new drugs in castrate resistant prostate cancer including abiraterone acetate and enzalutamide (MDV3100).
This translational progress from “bench to bed-side” has resulted in an enlarging repertoire of novel and traditional drug choices now available for use in advanced prostate cancer therapeutics, which has had a positive clinical impact in prolonging longevity and quality of life of advanced prostate cancer patients.
In order to further the clinical utility of these drugs, development of predictive biomarkers guiding individual therapeutic choices remains an ongoing challenge.
This paper will summarize the potential in developing predictive biomarkers based on the pathophysiology of the androgen-AR axis in tumor tissue from patients with advanced prostate cancer as well as inherited variation in the patient’s genome.
Specific examples of rational clinical trial designs incorporating potential predictive biomarkers from these pathways will illustrate several aspects of pharmacogenetic and pharmacogenomic predictive biomarker development in advanced prostate cancer therapeutics.
American Psychological Association (APA)
Kohli, Manish& Qin, Rui& Jimenez, Rafael& Dehm, Scott M.. 2012. Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer. Advances in Urology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-497509
Modern Language Association (MLA)
Kohli, Manish…[et al.]. Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer. Advances in Urology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-497509
American Medical Association (AMA)
Kohli, Manish& Qin, Rui& Jimenez, Rafael& Dehm, Scott M.. Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-497509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497509