![](/images/graphics-bg.png)
Pyrazinamide Effects on Cartilage Type II Collagen Amino Acid Composition
Joint Authors
Kovalenko, Valentina M.
Bondarenko, Larysa B.
Source
International Journal of Peptides
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction.
Current therapeutic regimens with first-line antitubercular agents are associated to a high rate of adverse effects which could cause pronounced changes in collagen's contents and structure.
Investigation of these changes is very important for optimization of antitubercular therapy and minimization of treatment-caused harm.
The aim of present paper was to investigate potential effect of pyrazinamide on male rats' cartilage type II collagen amino acid composition.
Materials and Methods.
Wistar albino male rats (160–200 g b.w.) were divided into three groups: I—received pyrazinamide per os at a dose of 1000 mg/kg b.w./day; II—at a dose of 2000 mg/kg b.w./day, in both groups it was given for 60 days; III—control.
After 60 days of the experiment, rats of the experimental (groups I and II) and control groups were sacrificed and the amino acids contents of male rat cartilage type II collagens were determined using amino acid analyzer.
Results and Discussion.
The study of pyrazinamide effects (administered in different doses) on rat cartilage type II collagen amino acid contents demonstrated presence of dose-dependent pyrazinamide-mediated quantitative and qualitative changes in these rat extracellular matrix proteins in comparison with control.
American Psychological Association (APA)
Bondarenko, Larysa B.& Kovalenko, Valentina M.. 2012. Pyrazinamide Effects on Cartilage Type II Collagen Amino Acid Composition. International Journal of Peptides،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-497550
Modern Language Association (MLA)
Bondarenko, Larysa B.& Kovalenko, Valentina M.. Pyrazinamide Effects on Cartilage Type II Collagen Amino Acid Composition. International Journal of Peptides No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-497550
American Medical Association (AMA)
Bondarenko, Larysa B.& Kovalenko, Valentina M.. Pyrazinamide Effects on Cartilage Type II Collagen Amino Acid Composition. International Journal of Peptides. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-497550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497550