Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP) and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa)
Joint Authors
Berzosa, Pedro
Nlang, Natividad
Micha, Anastasio
Raso, Jose
Benito, Agustín
Lwanga, Magdalena
Roche, Jesús
Nsee, Natividad
Obono, Jacqueline
de Lucio, Aida
Nchama, Araceli
Descalzo, Miguel Angel
Mangue, Catalina
Charle, Pilar
Mesie, Rosario
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
The objectives of the study were (i) to evaluate the efficacy of combination drugs, such as artesunate + sulphadoxine-pyrimethamine (AS + SP) and amodiaquine + sulphadoxine-pyripethamine (AQ + SP) in treatment of uncomplicated falciparum malaria (ii) to differentiate recrudescence from reinfection by analysing msp-1 and msp-2 genes of Plasmodium falciparum in treatment failure cases.
Methods.
We carried out an in vivo study in the year 2005 in 206 children between 6 to 59 months age groups.
Of the 206, 120 received AQ + SP, and 86 received AS + SP.
A clinical and parasitological followup during 14 days was undertaken.
Finger-prick blood sample from each patient was taken on Whatman filter paper (no.
3) on days 0, 7, 14 and also the day when the parasite and symptoms reappeared for PCR analysis.
Results.
Late treatment failure was observed in 3.5% (4/114) with AQ + SP, and 2.5% (2/79) with AS + SP.
The success rate was 96.5% with AQ + SP and 97.5% with AS + SP.
No deaths and severe reactions were recorded.
Out of the 6 treatment failure cases, one was reinfection as observed by PCR analysis of msp-1 and msp-2 genes on day 14.
Discussion.
Both the combinations found to be efficacious and safe and could be used as a first-line treatment for uncomplicated falciparum malaria in Equatorial Guinea.
American Psychological Association (APA)
Charle, Pilar& Berzosa, Pedro& Descalzo, Miguel Angel& de Lucio, Aida& Raso, Jose& Obono, Jacqueline…[et al.]. 2009. Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP) and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa). Journal of Tropical Medicine،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-497557
Modern Language Association (MLA)
Charle, Pilar…[et al.]. Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP) and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa). Journal of Tropical Medicine No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-497557
American Medical Association (AMA)
Charle, Pilar& Berzosa, Pedro& Descalzo, Miguel Angel& de Lucio, Aida& Raso, Jose& Obono, Jacqueline…[et al.]. Efficacy of Artesunate + Sulphadoxine-Pyrimethamine (AS + SP) and Amodiaquine + Sulphadoxine-Pyrimethamine (AQ + SP) for Uncomplicated falciparum Malaria in Equatorial Guinea (Central Africa). Journal of Tropical Medicine. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-497557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497557