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Metabolic Syndrome and Inflammation : A Critical Review of In Vitro and Clinical Approaches for Benefit Assessment of Plant Food Supplements
Joint Authors
Restani, Patrizia
Dell'Agli, Mario
Di Lorenzo, Chiara
Colombo, Elisa
Sangiovanni, Enrico
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Metabolic syndrome is defined as the clustering in an individual of several metabolic abnormalities associated with insulin resistance, type 2 diabetes, and obesity, in which low-grade chronic inflammatory activity is commonly observed.
Part of the European Project PlantLIBRA is concerned with methods to assess the benefits of plant food supplements (PFSs) in countering inflammatory activity and metabolic syndrome.
This paper summarizes the current methods used for benefit assessment of PFS, taking into consideration only in vitro, in silico, and clinical methodologies used to investigate the anti-inflammatory properties of plants.
No in silico studies (using computer simulation) related to metabolic syndrome were found; these methods appear to be used exclusively for identifying or testing potentially effective compounds in drug development.
Most in vitro methods for the assessment of beneficial effects of botanicals or plant food supplements in diabetes were based on a quantitative polymerase chain reaction (PCR), whereas the preferred kind of clinical study was the double-blind randomized controlled clinical trial.
Only two parameters were observed to change after treatment with botanicals in both in vitro and in vivo studies: interleukin-6 and tumour necrosis factor-α, and these biomarkers should be carefully considered in future studies for PFS benefit assessment.
American Psychological Association (APA)
Di Lorenzo, Chiara& Dell'Agli, Mario& Colombo, Elisa& Sangiovanni, Enrico& Restani, Patrizia. 2013. Metabolic Syndrome and Inflammation : A Critical Review of In Vitro and Clinical Approaches for Benefit Assessment of Plant Food Supplements. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497615
Modern Language Association (MLA)
Di Lorenzo, Chiara…[et al.]. Metabolic Syndrome and Inflammation : A Critical Review of In Vitro and Clinical Approaches for Benefit Assessment of Plant Food Supplements. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-497615
American Medical Association (AMA)
Di Lorenzo, Chiara& Dell'Agli, Mario& Colombo, Elisa& Sangiovanni, Enrico& Restani, Patrizia. Metabolic Syndrome and Inflammation : A Critical Review of In Vitro and Clinical Approaches for Benefit Assessment of Plant Food Supplements. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497615