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Astragalus Polysaccharide Suppresses Skeletal Muscle Myostatin Expression in Diabetes : Involvement of ROS-ERK and NF-κB Pathways
Joint Authors
Liu, Min
Luo, Tao
Luo, Jun
Hao, Yarong
Wei, Lei
Qin, Jian
Liu, Min
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Objective.
The antidiabetes drug astragalus polysaccharide (APS) is capable of increasing insulin sensitivity in skeletal muscle and improving whole-body glucose homeostasis.
Recent studies suggest that skeletal muscle secreted growth factor myostatin plays an important role in regulating insulin signaling and insulin resistance.
We hypothesized that regulation of skeletal muscle myostatin expression may be involved in the improvement of insulin sensitivity by APS.
Methods.
APS was administered to 13-week-old diabetic KKAy and nondiabetic C57BL/6J mice for 8 weeks.
Complementary studies examined APS effects on the saturated acid palmitate-induced insulin resistance and myostatin expression in C2C12 cells.
Results.
APS treatment ameliorated hyperglycemia, hyperlipidemia, and insulin resistance and decreased the elevation of myostatin expression and malondialdehyde production in skeletal muscle of noninsulin-dependent diabetic KKAy mice.
In C2C12 cells in vitro, saturated acid palmitate-induced impaired glucose uptake, overproduction of ROS, activation of extracellular regulated protein kinases (ERK), and NF-κB were partially restored by APS treatment.
The protective effects of APS were mimicked by ERK and NF-κB inhibitors, respectively.
Conclusion.
Our study demonstrates elevated myostatin expression in skeletal muscle of type 2 diabetic KKAy mice and in cultured C2C12 cells exposed to palmitate.
APS is capable of improving insulin sensitivity and decreasing myostatin expression in skeletal muscle through downregulating ROS-ERK-NF-κB pathway.
American Psychological Association (APA)
Liu, Min& Qin, Jian& Hao, Yarong& Liu, Min& Luo, Jun& Luo, Tao…[et al.]. 2013. Astragalus Polysaccharide Suppresses Skeletal Muscle Myostatin Expression in Diabetes : Involvement of ROS-ERK and NF-κB Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497622
Modern Language Association (MLA)
Liu, Min…[et al.]. Astragalus Polysaccharide Suppresses Skeletal Muscle Myostatin Expression in Diabetes : Involvement of ROS-ERK and NF-κB Pathways. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-497622
American Medical Association (AMA)
Liu, Min& Qin, Jian& Hao, Yarong& Liu, Min& Luo, Jun& Luo, Tao…[et al.]. Astragalus Polysaccharide Suppresses Skeletal Muscle Myostatin Expression in Diabetes : Involvement of ROS-ERK and NF-κB Pathways. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497622