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Doripenem Dosing Recommendations for Critically Ill Patients Receiving Continuous Renal Replacement Therapy
Joint Authors
Nandy, Partha
Vaccaro, Nicole
Redman, Rebecca
Matzke, Gary R.
Cirillo, Iolanda
Samtani, Mahesh N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Doripenem dosing regimens for patients receiving continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodiafiltration (CVVHDF) were devised based on an established efficacy criterion (free plasma doripenem concentrations above the minimum inhibitory concentration [fT>MIC] of 1 mg/L for ≥35% of the dosing interval) while maintaining exposure below that with the highest studied dose of 1000 mg infused over 1 hour every 8 hours in healthy subjects.
Simulations were utilized to assure ≥90% probability of achieving the efficacy criterion with the recommended doripenem regimens.
Inflated intersubject variability of 40% (coefficient of variation) was used for pharmacokinetic parameters (representative of clinical variation) and nonrenal clearance was doubled to account for potential changes with acute renal insufficiency.
Results indicate that a reduction in doripenem dose will be needed for critically ill patients receiving CVVH or CVVHDF.
This work was conducted to fulfill a health authority request and resulted in the addition of dosing recommendations to the Doribax Summary of Product Characteristics.
American Psychological Association (APA)
Samtani, Mahesh N.& Vaccaro, Nicole& Cirillo, Iolanda& Matzke, Gary R.& Redman, Rebecca& Nandy, Partha. 2012. Doripenem Dosing Recommendations for Critically Ill Patients Receiving Continuous Renal Replacement Therapy. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-497649
Modern Language Association (MLA)
Samtani, Mahesh N.…[et al.]. Doripenem Dosing Recommendations for Critically Ill Patients Receiving Continuous Renal Replacement Therapy. ISRN Pharmacology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-497649
American Medical Association (AMA)
Samtani, Mahesh N.& Vaccaro, Nicole& Cirillo, Iolanda& Matzke, Gary R.& Redman, Rebecca& Nandy, Partha. Doripenem Dosing Recommendations for Critically Ill Patients Receiving Continuous Renal Replacement Therapy. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-497649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497649