Glucagon Effects on 3H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis
Joint Authors
Rosic, Mirko
Parodi, Oberdan
Jokovic, Vuk
Jakovljevic, Vladimir Lj.
Zivkovic, Vladimir I.
Colic, Maja
Pantovic, Suzana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We estimated the influence of acute glucagon applications on 3H-histamine uptake by the isolated guinea-pig heart, during a single 3H-histamine passage through the coronary circulation, before and during anaphylaxis, and the influence of glucagon on level of histamine, NO, O2-, and H2O2 in the venous effluent during anaphylaxis.
Before anaphylaxis, glucagon pretreatment does not change 3H-histamine Umax and the level of endogenous histamine.
At the same time, in the presence of glucagon, 3H-histamine Unet is increased and backflux is decreased when compared to the corresponding values in the absence of glucagon.
During anaphylaxis, in the presence of glucagon, the values of 3H-histamine Umax and Unet are significantly higher and backflux is significantly lower in the presence of glucagon when compared to the corresponding values in the absence of glucagon.
The level of endogenous histamine during anaphylaxis in the presence of glucagon (6.9–7.38 × 10−8 μM) is significantly lower than the histamine level in the absence of glucagon (10.35–10.45 × 10−8 μM).
Glucagon pretreatment leads to a significant increase in NO release (5.69 nmol/mL) in comparison with the period before glucagon administration (2.49 nmol/mL).
Then, in the presence of glucagon, O2- level fails to increase during anaphylaxis.
Also, our results show no significant differences in H2O2 levels before, during, and after anaphylaxis in the presence of glucagon, but these values are significantly lower than the corresponding values in the absence of glucagon.
In conclusion, our results show that glucagon increases NO release and prevents the increased release of free radicals during anaphylaxis, and decreases histamine level in the venous effluent during cardiac anaphylaxis, which may be a consequence of decreased histamine release and/or intensified histamine capturing by the heart during anaphylaxis.
American Psychological Association (APA)
Rosic, Mirko& Parodi, Oberdan& Jakovljevic, Vladimir Lj.& Colic, Maja& Zivkovic, Vladimir I.& Jokovic, Vuk…[et al.]. 2014. Glucagon Effects on 3H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-497652
Modern Language Association (MLA)
Rosic, Mirko…[et al.]. Glucagon Effects on 3H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-497652
American Medical Association (AMA)
Rosic, Mirko& Parodi, Oberdan& Jakovljevic, Vladimir Lj.& Colic, Maja& Zivkovic, Vladimir I.& Jokovic, Vuk…[et al.]. Glucagon Effects on 3H-Histamine Uptake by the Isolated Guinea-Pig Heart during Anaphylaxis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-497652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497652