Polo-Like Kinase 1 : A Novel Target for the Treatment of Therapy-Resistant Mantle Cell Lymphoma
Joint Authors
Ahrens, Adam K.
Joshi, Shantaram S.
Vose, Julie M.
Shukla, Ashima
Chaturvedi, Nagendra K.
Hegde, Ganapati V.
Nordgren, Tara M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma (NHL) which is one of the most aggressive lymphomas.
Despite recent improvements in therapies, the development of therapy-resistance is still a major problem; therefore, in order to understand the molecular basis of therapy-resistance, stable therapy-resistant MCL cell lines have been established by us.
Based on the gene expression profiles of these cell lines, Polo-like kinase 1 (PLK1) was chosen as a therapeutic target.
In this paper, we demonstrate a significant antilymphoma effect of targeting PLK1 in therapy-resistant MCL cells and primary MCL cells from refractory patients.
PLK1 knockdown with the antisense oligonucleotide (ASO)/or small molecule inhibitor BI2536 showed significantly decreased proliferation and increased apoptosis in therapy-resistant MCL cell lines and MCL primary cells.
Additionally, the direct protein-protein interaction partners of PLK1 were mapped using ingenuity pathway and confirmed the level of association of these partners with PLK1 based on their expression changes following PLK1 knockdown using real-time PCR.
Results suggest that PLK1 is a viable target for the treatment of therapy-resistant MCL.
American Psychological Association (APA)
Ahrens, Adam K.& Chaturvedi, Nagendra K.& Shukla, Ashima& Nordgren, Tara M.& Hegde, Ganapati V.& Vose, Julie M.…[et al.]. 2013. Polo-Like Kinase 1 : A Novel Target for the Treatment of Therapy-Resistant Mantle Cell Lymphoma. Lymphoma،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497670
Modern Language Association (MLA)
Ahrens, Adam K.…[et al.]. Polo-Like Kinase 1 : A Novel Target for the Treatment of Therapy-Resistant Mantle Cell Lymphoma. Lymphoma No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-497670
American Medical Association (AMA)
Ahrens, Adam K.& Chaturvedi, Nagendra K.& Shukla, Ashima& Nordgren, Tara M.& Hegde, Ganapati V.& Vose, Julie M.…[et al.]. Polo-Like Kinase 1 : A Novel Target for the Treatment of Therapy-Resistant Mantle Cell Lymphoma. Lymphoma. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497670