Lymphatics and Lymphangiogenesis in the Eye
Joint Authors
Ishibashi, Tatsuro
Hafezi-Moghadam, Ali
Nakao, Shintaro
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lymphatic is a prerequisite for the maintenance of tissue fluid balance and immunity in the body.
A body of evidence also shows that lymphangiogenesis plays important roles in the pathogenesis of diseases such as tumor metastasis and inflammation.
The eye was thought to lack lymphatic vessels except for the conjunctiva; however, advances in the field, including the identification of lymphatic endothelial markers (e.g., LYVE-1 or podoplanin) and lymphangiogenic factors (e.g., VEGF-C), have revealed the exsitence and possible roles of lymphatics and lymphangiogenesis in the eye.
Recent studies have shown that corneal limbus, ciliary body, lacrimal gland, orbital meninges, and extraocular muscles contain lymphatic vessels and that the choroid might have a lymphatic-like system.
There is no known lymphatic outflow from the eye.
However, several lymphatic channels including uveolymphatic pathway might serve the ocular fluid homeostasis.
Furthermore, lymphangiogenesis plays important roles in pathological conditions in the eye including corneal transplant rejection and ocular tumor progression.
Yet, the role of lymphangiogenesis in most eye diseases, especially inflammatory disease or edema, remains unknown.
A better understanding of lymphatic and lymphangiogenesis in the eye will open new therapeutic opportunities to prevent vision loss in ocular diseases.
American Psychological Association (APA)
Nakao, Shintaro& Hafezi-Moghadam, Ali& Ishibashi, Tatsuro. 2012. Lymphatics and Lymphangiogenesis in the Eye. Journal of Ophthalmology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-497699
Modern Language Association (MLA)
Nakao, Shintaro…[et al.]. Lymphatics and Lymphangiogenesis in the Eye. Journal of Ophthalmology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-497699
American Medical Association (AMA)
Nakao, Shintaro& Hafezi-Moghadam, Ali& Ishibashi, Tatsuro. Lymphatics and Lymphangiogenesis in the Eye. Journal of Ophthalmology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-497699
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497699