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PPARs, Cardiovascular Metabolism, and Function : Near- or Far-from-Equilibrium Pathways
Joint Authors
Lecarpentier, Yves
Hébert, Jean-Louis
Claes, Victor
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptors (PPAR α, β/δ and γ) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system.
Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative stress.
In this review, we focus mainly on the effects of PPARs on some thermodynamic processes, which can behave either near equilibrium, or far-from-equilibrium.
New functions of PPARs are reported in the arrhythmogenic right ventricular cardiomyopathy, a human genetic heart disease.
It is now possible to link the genetic desmosomal abnormalitiy to the presence of fat in the right ventricle, partly due to an overexpression of PPARγ.
Moreover, PPARs are directly or indirectly involved in cellular oscillatory processes such as the Wnt-b-catenin pathway, circadian rhythms of arterial blood pressure and cardiac frequency and glycolysis metabolic pathway.
Dysfunction of clock genes and PPARγ may lead to hyperphagia, obesity, metabolic syndrome, myocardial infarction and sudden cardiac death, In pathological conditions, regulatory processes of the cardiovascular system may bifurcate towards new states, such as those encountered in hypertension, type 2 diabetes, and heart failure.
Numerous of these oscillatory mechanisms, organized in time and space, behave far from equilibrium and are “dissipative structures”.
American Psychological Association (APA)
Lecarpentier, Yves& Claes, Victor& Hébert, Jean-Louis. 2010. PPARs, Cardiovascular Metabolism, and Function : Near- or Far-from-Equilibrium Pathways. PPAR Research،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-497714
Modern Language Association (MLA)
Lecarpentier, Yves…[et al.]. PPARs, Cardiovascular Metabolism, and Function : Near- or Far-from-Equilibrium Pathways. PPAR Research No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-497714
American Medical Association (AMA)
Lecarpentier, Yves& Claes, Victor& Hébert, Jean-Louis. PPARs, Cardiovascular Metabolism, and Function : Near- or Far-from-Equilibrium Pathways. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-497714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497714