Thyroxine as a stimulator of liver regeneration after partial hepatectomy : an experimental animal study
Joint Authors
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 38, Issue 3 (31 Dec. 2008), pp.853-863, 11 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2008-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
Twenty six male albino rats were divided into a control group (6rats) (G) exposed to Sham operation and two experimental groups (G1 & G2) of 10 rats each.
2 / 3 partial hepatectomy (PH) was performed in G1 and T4 was administered orally in a dose of 4mg / kg 10 days prior to PH in G2.
Animals were sacrificed 24 hours following PH and Sham operation.
Liver sections were immunohistochemically stained for anti-cyclin D1 & anti-VEGF antibodies.
Positive reaction was in the nuclei of hepatocytes and in lining of hepatic blood sinusoids respectively.
The morphometric determination of the count of cyclin D1 positive nuclei and area % VEGF positive lining of the blood sinusoids was performed in the different groups.
Multiple cyclin D1 positive nuclei were detected in liver sections of rats receiving thyroxine prior to PH confirmed by significant increase in the mean count of immuno-positive nuclei as compared to G & G1.
VEGF positive immuno-reaction was in the lining of multiple hepatic blood sinusoids on thyroxine therapy proved morphometrically by a significant increase in mean area % in G2 versus G1.
The results showed a stimulating effect of thyroxine on liver regeneration following 2 / 3 partial hepatectomy evidenced by increased Cyclin D and sinusoidal endothelial VEGF expression.
American Psychological Association (APA)
Rida, Mahmud& Zakariyya, Maha. 2008. Thyroxine as a stimulator of liver regeneration after partial hepatectomy : an experimental animal study. Journal of the Egyptian Society of Parasitology،Vol. 38, no. 3, pp.853-863.
https://search.emarefa.net/detail/BIM-49776
Modern Language Association (MLA)
Rida, Mahmud& Zakariyya, Maha. Thyroxine as a stimulator of liver regeneration after partial hepatectomy : an experimental animal study. Journal of the Egyptian Society of Parasitology Vol. 38, no. 3 (Dec. 2008), pp.853-863.
https://search.emarefa.net/detail/BIM-49776
American Medical Association (AMA)
Rida, Mahmud& Zakariyya, Maha. Thyroxine as a stimulator of liver regeneration after partial hepatectomy : an experimental animal study. Journal of the Egyptian Society of Parasitology. 2008. Vol. 38, no. 3, pp.853-863.
https://search.emarefa.net/detail/BIM-49776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 959-961
Record ID
BIM-49776