Inhibitory Potential of Turbinaria ornata against Key Metabolic Enzymes Linked to Diabetes
Joint Authors
Jayasri, M. A.
Suthindhiran, K.
Unnikrishnan, P. S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
One of the therapeutic approaches in treating diabetes is to reduce postprandial hyperglycemia by inhibiting major carbohydrate hydrolyzing enzymes.
In the present study, crude extracts of marine seaweed, Turbinaria ornata, were tested for their antidiabetic potential using enzyme inhibitory assays (α-amylase, α-glucosidase, and dipeptidyl peptidase-IV).
Among the tested extracts, methanol and acetone extracts showed significant inhibitory effects on α-amylase (IC50 250.9 μg/mL), α-glucosidase (535.6 μg/mL), and dipeptidyl peptidase-4 (55.2 μg/mL), respectively.
Free radical scavenging activity of these extracts was analyzed using DPPH assay (65%).
Extracts were tested for in vitro toxicity using DNA fragmentation assay, haemolytic assay, and MTT assay.
None of the extracts showed toxicity in tested models.
Furthermore, GC-MS analysis of lead extracts showed the presence of major compounds, hentriacontane, z, z-6, 28-heptatriactontadien-2-one, 8-heptadecene, and 1-heptacosanol.
Our findings suggest that Turbinaria ornata can be used as a potential source for further in vivo studies in controlling hyperglycemia.
American Psychological Association (APA)
Unnikrishnan, P. S.& Suthindhiran, K.& Jayasri, M. A.. 2014. Inhibitory Potential of Turbinaria ornata against Key Metabolic Enzymes Linked to Diabetes. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-497771
Modern Language Association (MLA)
Unnikrishnan, P. S.…[et al.]. Inhibitory Potential of Turbinaria ornata against Key Metabolic Enzymes Linked to Diabetes. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-497771
American Medical Association (AMA)
Unnikrishnan, P. S.& Suthindhiran, K.& Jayasri, M. A.. Inhibitory Potential of Turbinaria ornata against Key Metabolic Enzymes Linked to Diabetes. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-497771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497771