Acute Myocardial Infarction Caused by Filgrastim : A Case Report

Abstract EN

Common uses of the granulocyte-colony stimulating factors in the clinical practice raise the concern about side effects of these agents.

We presented a case report about an acute myocardial infarction with non-ST segment elevation during filgrastim administration.

A 73-year-old man had squamous cell carcinoma of larynx with lung metastasis treated with the chemotherapy.

Second day after the filgrastim, patient had a chest discomfort.

An ECG was performed and showed an ST segment depression and negative T waves on inferior derivations.

A coronary angiography had showed a critical lesion in right coronary arteria.

This is the first study thats revealed that G-CSF can cause acute myocardial infarction in cancer patients without history of cardiac disease.

Patients with chest discomfort and pain who are on treatment with G-CSF or GM-CSF must alert the physicians for acute coronary events.