Both Maternal and Pup Genotype Influence Ultrasonic Vocalizations and Early Developmental Milestones in Tsc2+− Mice
Joint Authors
Sahin, Mustafa
Greene-Colozzi, Emily A.
Sadowski, Abbey R.
Tsai, Peter T.
Chadwick, Elyza
Source
Epilepsy Research and Treatment
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by tumor growth and neuropsychological symptoms such as autistic behavior, developmental delay, and epilepsy.
While research has shed light on the biochemical and genetic etiology of TSC, the pathogenesis of the neurologic and behavioral manifestations remains poorly understood.
TSC patients have a greatly increased risk of developmental delay and autism spectrum disorder, rendering the relationship between the two sets of symptoms an extremely pertinent issue for clinicians.
We have expanded on previous observations of aberrant vocalizations in Tsc2+/− mice by testing vocalization output and developmental milestones systematically during the early postnatal period.
In this study, we have demonstrated that Tsc2 haploinsufficiency in either dams or their pups results in a pattern of developmental delay in sensorimotor milestones and ultrasonic vocalizations.
American Psychological Association (APA)
Greene-Colozzi, Emily A.& Sadowski, Abbey R.& Chadwick, Elyza& Tsai, Peter T.& Sahin, Mustafa. 2014. Both Maternal and Pup Genotype Influence Ultrasonic Vocalizations and Early Developmental Milestones in Tsc2+− Mice. Epilepsy Research and Treatment،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-497798
Modern Language Association (MLA)
Greene-Colozzi, Emily A.…[et al.]. Both Maternal and Pup Genotype Influence Ultrasonic Vocalizations and Early Developmental Milestones in Tsc2+− Mice. Epilepsy Research and Treatment No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-497798
American Medical Association (AMA)
Greene-Colozzi, Emily A.& Sadowski, Abbey R.& Chadwick, Elyza& Tsai, Peter T.& Sahin, Mustafa. Both Maternal and Pup Genotype Influence Ultrasonic Vocalizations and Early Developmental Milestones in Tsc2+− Mice. Epilepsy Research and Treatment. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-497798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497798