Nonengraftment Haploidentical Cellular Therapy for Hematologic Malignancies
Joint Authors
Reagan, John L.
Winer, Eric S.
Fast, Loren D.
Safran, Howard
Butera, James N.
Quesenberry, Peter J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Much of the therapeutic benefit of allogeneic transplant is by a graft versus tumor effect.
Further data shows that transplant engraftment is not dependant on myeloablation, instead relying on quantitative competition between donor and host cells.
In the clinical setting, engraftment by competition alone is not feasible due to the need for large numbers of infused cells.
Instead, low-level host irradiation has proven to be an effective engraftment strategy that is stem cell toxic but not myeloablative.
The above observations served as the foundation for clinical trials utilizing allogeneic matched and haploidentical peripheral blood stem cell infusions with minimal conditioning in patients with refractory malignancies.
Although engraftment was transient or not apparent, there were compelling responses in a heavily pretreated patient population that appear to result from the breaking of tumor immune tolerance by the host through the actions of IFNγ, invariant NK T cells, CD8 T cells, NK cells, or antigen presenting cells.
American Psychological Association (APA)
Reagan, John L.& Fast, Loren D.& Winer, Eric S.& Safran, Howard& Butera, James N.& Quesenberry, Peter J.. 2012. Nonengraftment Haploidentical Cellular Therapy for Hematologic Malignancies. Advances in Hematology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497807
Modern Language Association (MLA)
Reagan, John L.…[et al.]. Nonengraftment Haploidentical Cellular Therapy for Hematologic Malignancies. Advances in Hematology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-497807
American Medical Association (AMA)
Reagan, John L.& Fast, Loren D.& Winer, Eric S.& Safran, Howard& Butera, James N.& Quesenberry, Peter J.. Nonengraftment Haploidentical Cellular Therapy for Hematologic Malignancies. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497807