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Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of obob Mice
Joint Authors
Frühbeck, Gema
Ramírez, Beatriz
Becerril, Sara
Gómez-Ambrosi, Javier
Catalán, Victoria
Rodríguez, Amaia
Sáinz, Neira
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Obese leptin-deficient ob/ob mice exhibit a low-grade chronic inflammation together with a low muscle mass.
Our aim was to analyze the changes in muscle expression levels of genes related to oxidative stress and inflammatory responses in leptin deficiency and to identify the effect of in vivo leptin administration.
Ob/ob mice were divided in three groups as follows: control ob/ob, leptin-treated ob/ob (1 mg/kg/d) and leptin pair-fed ob/ob mice.
Gastrocnemius weight was lower in control ob/ob than in wild type mice (P<.01) exhibiting an increase after leptin treatment compared to control and pair-fed (P<.01) ob/ob animals.
Thiobarbituric acid reactive substances, markers of oxidative stress, were higher in serum (P<.01) and gastrocnemius (P=.05) of control ob/ob than in wild type mice and were significantly decreased (P<.01) by leptin treatment.
Leptin deficiency altered the expression of 1,546 genes, while leptin treatment modified the regulation of 1,127 genes with 86 of them being involved in oxidative stress, immune defense and inflammatory response.
Leptin administration decreased the high expression of Crybb1, Hspb3, Hspb7, Mt4, Cat, Rbm9, Serpinc1 and Serpinb1a observed in control ob/ob mice, indicating that it improves inflammation and muscle loss.
American Psychological Association (APA)
Sáinz, Neira& Rodríguez, Amaia& Catalán, Victoria& Becerril, Sara& Ramírez, Beatriz& Gómez-Ambrosi, Javier…[et al.]. 2010. Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of obob Mice. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-497818
Modern Language Association (MLA)
Sáinz, Neira…[et al.]. Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of obob Mice. Mediators of Inflammation No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-497818
American Medical Association (AMA)
Sáinz, Neira& Rodríguez, Amaia& Catalán, Victoria& Becerril, Sara& Ramírez, Beatriz& Gómez-Ambrosi, Javier…[et al.]. Leptin Administration Downregulates the Increased Expression Levels of Genes Related to Oxidative Stress and Inflammation in the Skeletal Muscle of obob Mice. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-497818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497818