Immune Response to a Variable Pathogen : A Stochastic Model with Two Interlocked Darwinian Entities
Author
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
This paper presents the modeling of a host immune system, more precisely the immune effector cell and immune memory cell population, and its interaction with an invading pathogen population.
It will tackle two issues of interest; on the one hand, in defining a stochastic model accounting for the inherent nature of organisms in population dynamics, namely multiplication with mutation and selection; on the other hand, in providing a description of pathogens that may vary their antigens through mutations during infection of the host.
Unlike most of the literature, which models the dynamics with first-order differential equations, this paper proposes a Galton-Watson type branching process to describe stochastically by whole distributions the population dynamics of pathogens and immune cells.
In the first model case, the pathogen of a given type is either eradicated or shows oscillatory chronic response.
In the second model case, the pathogen shows variational behavior changing its antigen resulting in a prolonged immune reaction.
American Psychological Association (APA)
Kuhn, Christoph. 2012. Immune Response to a Variable Pathogen : A Stochastic Model with Two Interlocked Darwinian Entities. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-497828
Modern Language Association (MLA)
Kuhn, Christoph. Immune Response to a Variable Pathogen : A Stochastic Model with Two Interlocked Darwinian Entities. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-497828
American Medical Association (AMA)
Kuhn, Christoph. Immune Response to a Variable Pathogen : A Stochastic Model with Two Interlocked Darwinian Entities. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-497828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497828