The Chylomicron : Relationship to Atherosclerosis
Joint Authors
Owens, Daphne
Tomkin, Gerald H.
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The B-containing lipoproteins are the transporters of cholesterol, and the evidence suggests that the apo B48-containing postprandial chylomicron particles and the triglyceride-rich very low density lipoprotein (VLDL) particles play an important part in the development of the plaque both directly and indirectly by their impact on LDL composition.
The ratio of dietary to synthesised cholesterol is variable but tightly regulated: hence intervention with diet at best reduces serum cholesterol by <20% andusually <10%.
Statins are the mainstay of cholesterol reduction therapy, but they increase cholesterol absorption, an example of the relationship between synthesis and absorption.
Inhibition of cholesterol absorption with Ezetimibe, an inhibitor of Niemann Pick C1-like 1 (NPC1-L1), the major regulator of cholesterol absorption, increases cholesterol synthesis and hence the value of adding an inhibitor of cholesterol absorption to an inhibitor of cholesterol synthesis.
Apo B48, the structural protein of the chylomicron particle, is synthesised in abundance so that the release of these particles is dependent on the amount of cholesterol and triglyceride available in the intestine.
This paper will discuss cholesterol absorption and synthesis, chylomicron formation, and the effect of postprandial lipoproteins on factors involved in atherosclerosis.
American Psychological Association (APA)
Tomkin, Gerald H.& Owens, Daphne. 2011. The Chylomicron : Relationship to Atherosclerosis. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-497831
Modern Language Association (MLA)
Tomkin, Gerald H.& Owens, Daphne. The Chylomicron : Relationship to Atherosclerosis. International Journal of Vascular Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-497831
American Medical Association (AMA)
Tomkin, Gerald H.& Owens, Daphne. The Chylomicron : Relationship to Atherosclerosis. International Journal of Vascular Medicine. 2011. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-497831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497831