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Comparative Biomechanical and Microstructural Analysis of Native versus Peracetic Acid-Ethanol Treated Cancellous Bone Graft
Joint Authors
Günther, Klaus-Peter
Gelinsky, Michael
Rauh, Juliane
Baas, Jorgen
Stiehler, Maik
Pruss, Axel
Liebers, Cornelia
Despang, Florian
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bone transplantation is frequently used for the treatment of large osseous defects.
The availability of autologous bone grafts as the current biological gold standard is limited and there is a risk of donor site morbidity.
Allogenic bone grafts are an appealing alternative, but disinfection should be considered to reduce transmission of infection disorders.
Peracetic acid-ethanol (PE) treatment has been proven reliable and effective for disinfection of human bone allografts.
The purpose of this study was to evaluate the effects of PE treatment on the biomechanical properties and microstructure of cancellous bone grafts (CBG).
Forty-eight human CBG cylinders were either treated by PE or frozen at −20°C and subjected to compression testing and histological and scanning electron microscopy (SEM) analysis.
The levels of compressive strength, stiffness (Young’s modulus), and fracture energy were significantly decreased upon PE treatment by 54%, 59%, and 36%, respectively.
Furthermore, PE-treated CBG demonstrated a 42% increase in ultimate strain.
SEM revealed a modified microstructure of CBG with an exposed collagen fiber network after PE treatment.
We conclude that the observed reduced compressive strength and reduced stiffness may be beneficial during tissue remodeling thereby explaining the excellent clinical performance of PE-treated CBG.
American Psychological Association (APA)
Rauh, Juliane& Despang, Florian& Baas, Jorgen& Liebers, Cornelia& Pruss, Axel& Gelinsky, Michael…[et al.]. 2014. Comparative Biomechanical and Microstructural Analysis of Native versus Peracetic Acid-Ethanol Treated Cancellous Bone Graft. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-497847
Modern Language Association (MLA)
Rauh, Juliane…[et al.]. Comparative Biomechanical and Microstructural Analysis of Native versus Peracetic Acid-Ethanol Treated Cancellous Bone Graft. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-497847
American Medical Association (AMA)
Rauh, Juliane& Despang, Florian& Baas, Jorgen& Liebers, Cornelia& Pruss, Axel& Gelinsky, Michael…[et al.]. Comparative Biomechanical and Microstructural Analysis of Native versus Peracetic Acid-Ethanol Treated Cancellous Bone Graft. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-497847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497847