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Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver
Joint Authors
Carnevale, Roberto
Loffredo, Lorenzo
Del Ben, Maria
Pignatelli, Pasquale
Polimeni, Licia
Angelico, Francesco
Baratta, F.
Violi, Francesco
Bartimoccia, S.
Source
International Journal of Hepatology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background & Aims.
Hepatocyte apoptosis may play a role in progression of nonalcoholic fatty liver and oxidative stress seems one of the key mechanisms responsible for liver damage.
The aim was to determine the association of oxidative stress with cytokeratin-18 M30 fragment levels, a marker of hepatocyte apoptosis.
Methods.
Steatosis severity was defined according to Hamaguchi’s echographic criteria in 209 patients with nonalcoholic fatty liver.
Serum cytokeratin-18, urinary 8-iso-prostaglandin F2α, soluble NOX2-derived peptide, and adiponectin were measured.
Results.
Serum cytokeratin-18 progressively increased with steatosis severity (from 169.5 (129.3/183.8) to 176 (140/190) and 180 (169.5/192.5) μIU/mL in mild, moderate, and severe steatosis, respectively; P<0.01).
After stratification by cytokeratin-18 tertiles, a significant progression of body mass index, HOMA-IR, triglycerides, urinary 8-iso-PGF2α, soluble NOX2-derived peptide, and of the prevalence of diabetes and severe steatosis was found, while HDL-cholesterol and adiponectin progressively decreased.
A positive correlation between cytokeratin-18 and body mass index, HOMA-IR, Hamaguchi’s score, urinary 8-iso-PGF2α, and soluble NOX2-derived peptide and a negative correlation between cytokeratin-18 and HDL-cholesterol and adiponectin were found.
Body mass index, adiponectin, and soluble NOX2-derived peptide were independent predictors of serum cytokeratin-18 levels (adjusted R2=0.36).
Conclusion.
We support an association between oxidative stress and severity of liver damage in patients with nonalcoholic fatty liver.
American Psychological Association (APA)
Del Ben, Maria& Polimeni, Licia& Baratta, F.& Bartimoccia, S.& Carnevale, Roberto& Loffredo, Lorenzo…[et al.]. 2014. Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-497875
Modern Language Association (MLA)
Del Ben, Maria…[et al.]. Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver. International Journal of Hepatology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-497875
American Medical Association (AMA)
Del Ben, Maria& Polimeni, Licia& Baratta, F.& Bartimoccia, S.& Carnevale, Roberto& Loffredo, Lorenzo…[et al.]. Serum Cytokeratin-18 Is Associated with NOX2-Generated Oxidative Stress in Patients with Nonalcoholic Fatty Liver. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-497875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497875