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Different Angiogenic Abilities of Self-Setting Calcium Phosphate Cement Scaffolds Consisting of Different Proportions of Fibrin Glue
Joint Authors
Cui, Geng
Fan, Junjun
Xiu, Jintao
Li, Jie
Lei, Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To investigate the different angiogenic abilities of the self-setting calcium phosphate cement (CPC) consisting of different proportions of fibrin glue (FG), the CPC powder and the FG solution were mixed at the powder/liquid (P/L) ratios of 1 : 0.5, 1 : 1, and 1 : 2 (g/mL), respectively, and pure CPC was used as a control.
After being implanted into the lumbar dorsal fascia of the rabbit, the angiogenic process was evaluated by histological examination and CD31 immunohistochemistry to detect the new blood vessels.
The result of the new blood vessel showed that the P/L ratio of 1 : 1 group indicated the largest quantity of new blood vessel at 4 weeks, 8 weeks, and 12 weeks after implantation, respectively.
The histological evaluation also showed the best vascular morphology in the 1 : 1 group at 4 weeks, 8 weeks, and 12 weeks after the operation, respectively.
Our study indicated that the CPC-FG composite scaffold at the P/L ratio of 1 : 1 (g/mL) stimulated angiopoiesis better than any other P/L ratios and has significant potential as the bioactive material for the treatment of bone defects.
American Psychological Association (APA)
Xiu, Jintao& Fan, Junjun& Li, Jie& Cui, Geng& Lei, Wei. 2014. Different Angiogenic Abilities of Self-Setting Calcium Phosphate Cement Scaffolds Consisting of Different Proportions of Fibrin Glue. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-497891
Modern Language Association (MLA)
Xiu, Jintao…[et al.]. Different Angiogenic Abilities of Self-Setting Calcium Phosphate Cement Scaffolds Consisting of Different Proportions of Fibrin Glue. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-497891
American Medical Association (AMA)
Xiu, Jintao& Fan, Junjun& Li, Jie& Cui, Geng& Lei, Wei. Different Angiogenic Abilities of Self-Setting Calcium Phosphate Cement Scaffolds Consisting of Different Proportions of Fibrin Glue. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-497891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497891