The Effect of Captopril on Impaired Wound Healing in Experimental Diabetes
Joint Authors
Javanmard, Shaghayegh Haghjooy
Zandifar, Alireza
Sohrabi Beheshti, Sajedeh
Zandifar, Ehsan
Source
International Journal of Endocrinology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We aimed to investigate whether oral administration of captopril modulate wound healing, nitric oxide (NO), and vascular endothelial growth factor (VEGF) concentration in wound fluid of diabetic rats.
48 male Sprague-Dawley rats were divided in four groups (n=12).
The 36 rats were rendered diabetic by streptozotocin.
The animals of the first and second groups received 25 and 50 mg/kg/day captopril, respectively, (DM-cap25 and DM-cap50).
The animals of the third group were treated by distilled water (DM-control).
Control rats had no intervention.
The wound fluid level of NO and VEGF were measured.
Wound specimens were investigated histopathologically.
At the 5th day, there was significantly more NOx in wound fluid of DM-cap25 compared to other groups.
At the 7th day, both captopril-treated groups had more NOx in wound fluid compared to other groups.
At the 11th day, both captopril-treated groups had more NOx in wound fluid compared to DM-control group.
VEGF concentration was significantly higher in both captopril-treated groups versus DM-control group (P<.05).
There were significant higher wound healing scores in captopril-treated groups compared with DM-control group (P<.05).
These results suggest that captopril might be useful in diabetic wound healing.
American Psychological Association (APA)
Zandifar, Ehsan& Sohrabi Beheshti, Sajedeh& Zandifar, Alireza& Javanmard, Shaghayegh Haghjooy. 2012. The Effect of Captopril on Impaired Wound Healing in Experimental Diabetes. International Journal of Endocrinology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497902
Modern Language Association (MLA)
Zandifar, Ehsan…[et al.]. The Effect of Captopril on Impaired Wound Healing in Experimental Diabetes. International Journal of Endocrinology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-497902
American Medical Association (AMA)
Zandifar, Ehsan& Sohrabi Beheshti, Sajedeh& Zandifar, Alireza& Javanmard, Shaghayegh Haghjooy. The Effect of Captopril on Impaired Wound Healing in Experimental Diabetes. International Journal of Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497902