Effect of toxoplasma co-inefected with intestinal helminthes on cell mediated immunity to tuberculosis patients
Joint Authors
Abd al-Fattah, Muhyi al-Din M.
al-Motayam, Muna
al-Shami, Iman A.
Salim, Ghada A.
Sulayman, Amirah M.
Khurshid, Suha E.
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 38, Issue 3 (31 Dec. 2008), pp.895-902, 8 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2008-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
The effect of intestinal helminthes (IH) and Toxoplasma gondii (Tox) co-infection on anti-mycobacterium tuberculosis (MTB) immunity in patients with active pulmonary tuberculosis was studied in 96 patients of 4 groups.
Thirteen patients had TB + IH + Tox (G1), 15 had TB + IH (G2), 21 had TB + Tox (G3) and 47 had TB (G4).
The mean diameter of tuberculin and toxoplasmin tests was measured to assess cell mediated immunity.
Anti-Toxoplasma IgG1 & IgG4 antibodies were sought in toxoplasmic patients by ELISA for Thelper1 (Th1) and Th2 cytokine responses respectively.
All patients were treated by 6 months anti-MTB therapy.
Specific anti-IH therapies were given for patients with concomitant IH.
Sputum examination for acid fast bacilli was done 2 weeks post-treatment and duration of sputum clearance was recorded.
The results showed that IH co-infection had significant negative effect on mean diameter of tuberculin test compared to G4 (5.870.08 vs 8.65 0.05mm ; P < 0.01).
Concurrent Tox with TB significantly increased tuberculin test mean diameter (10.89 0.11 vs 8.65 0.05mm ; P < 0.05).
Mean level of anti-Tox IgG1 among G3 was significantly higher than in G1 (0.88 0.05vs0.55 0.02 ; P < 0.001), but vice versa was with IgG4.
Mean tuberculin diameter increased significantly post-treatment in all Gs except G3.
Anti-Tox IgG1 showed significant increase (0.55 0.02 to 0.82 0.03 ; P < 0.001) but IgG4 showed significant decrease (0.62 0.07 to 0.45 0.06, P < 0.01) post-treatment in G1, but G3 was insignificantly affected.
The duration of sputum cle arance was significantly longer in patients with IH co-infection compared to G4 (291 vs 21.84.6 days ; P < 0.001).
American Psychological Association (APA)
Abd al-Fattah, Muhyi al-Din M.& al-Shami, Iman A.& al-Motayam, Muna& Salim, Ghada A.& Sulayman, Amirah M.& Khurshid, Suha E.. 2008. Effect of toxoplasma co-inefected with intestinal helminthes on cell mediated immunity to tuberculosis patients. Journal of the Egyptian Society of Parasitology،Vol. 38, no. 3, pp.895-902.
https://search.emarefa.net/detail/BIM-49791
Modern Language Association (MLA)
Abd al-Fattah, Muhyi al-Din M.…[et al.]. Effect of toxoplasma co-inefected with intestinal helminthes on cell mediated immunity to tuberculosis patients. Journal of the Egyptian Society of Parasitology Vol. 38, no. 3 (Dec. 2008), pp.895-902.
https://search.emarefa.net/detail/BIM-49791
American Medical Association (AMA)
Abd al-Fattah, Muhyi al-Din M.& al-Shami, Iman A.& al-Motayam, Muna& Salim, Ghada A.& Sulayman, Amirah M.& Khurshid, Suha E.. Effect of toxoplasma co-inefected with intestinal helminthes on cell mediated immunity to tuberculosis patients. Journal of the Egyptian Society of Parasitology. 2008. Vol. 38, no. 3, pp.895-902.
https://search.emarefa.net/detail/BIM-49791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 900-902
Record ID
BIM-49791