Ion Channels and Zinc : Mechanisms of Neurotoxicity and Neurodegeneration
Joint Authors
Morris, Deborah R.
Levenson, Cathy W.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-07
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Ionotropic glutamate receptors, such as NMDA, AMPA and kainate receptors, are ligand-gated ion channels that mediate much of the excitatory neurotransmission in the brain.
Not only do these receptors bind glutamate, but they are also regulated by and facilitate the postsynaptic uptake of the trace metal zinc.
This paper discusses the role of the excitotoxic influx and accumulation of zinc, the mechanisms responsible for its cytotoxicity, and a number of disorders of the central nervous system that have been linked to these neuronal ion channels and zinc toxicity including ischemic brain injury, traumatic brain injury, and epilepsy.
American Psychological Association (APA)
Morris, Deborah R.& Levenson, Cathy W.. 2012. Ion Channels and Zinc : Mechanisms of Neurotoxicity and Neurodegeneration. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497937
Modern Language Association (MLA)
Morris, Deborah R.& Levenson, Cathy W.. Ion Channels and Zinc : Mechanisms of Neurotoxicity and Neurodegeneration. Journal of Toxicology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-497937
American Medical Association (AMA)
Morris, Deborah R.& Levenson, Cathy W.. Ion Channels and Zinc : Mechanisms of Neurotoxicity and Neurodegeneration. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-497937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497937