Feasibility of Predicting MCIAD Using Neuropsychological Tests and Serum β-Amyloid
Joint Authors
Luis, Cheryl A.
Mouzon, Benoit
Crawford, Fiona
Mullan, Michael
Ait-Ghezala, Ghania
Abdullah, Laila
Keegan, Andrew P.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We examined the usefulness of brief neuropsychological tests and serum Aβ as a predictive test for detecting MCI/AD in older adults.
Serum Aβ levels were measured from 208 subjects who were cognitively normal at enrollment and blood draw.
Twenty-eight of the subjects subsequently developed MCI (n=18) or AD (n=10) over the follow-up period.
Baseline measures of global cognition, memory, language fluency, and serum Aβ1–42 and the ratio of serum Aβ1–42/Aβ1–40 were significant predictors for future MCI/AD using Cox regression with demographic variables, APOE ε4, vascular risk factors, and specific medication as covariates.
An optimal sensitivity of 85.2% and specificity of 86.5% for predicting MCI/AD was achieved using ROC analyses.
Brief neuropsychological tests and measurements of Aβ1–42 obtained via blood warrants further study as a practical and cost effective method for wide-scale screening for identifying older adults who may be at-risk for pathological cognitive decline.
American Psychological Association (APA)
Luis, Cheryl A.& Abdullah, Laila& Ait-Ghezala, Ghania& Mouzon, Benoit& Keegan, Andrew P.& Crawford, Fiona…[et al.]. 2011. Feasibility of Predicting MCIAD Using Neuropsychological Tests and Serum β-Amyloid. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497989
Modern Language Association (MLA)
Luis, Cheryl A.…[et al.]. Feasibility of Predicting MCIAD Using Neuropsychological Tests and Serum β-Amyloid. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-497989
American Medical Association (AMA)
Luis, Cheryl A.& Abdullah, Laila& Ait-Ghezala, Ghania& Mouzon, Benoit& Keegan, Andrew P.& Crawford, Fiona…[et al.]. Feasibility of Predicting MCIAD Using Neuropsychological Tests and Serum β-Amyloid. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-497989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497989