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Citrate Anticoagulation for CRRT in Children : Comparison with Heparin
Joint Authors
Bellón, Jose María
Fernández, Sara Nicole
Alcaraz, Andrés José
García, Miriam
Santiago, Maria José
López-Herce, Jesús
Del Castillo, Jimena
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Regional anticoagulation with citrate is an alternative to heparin in continuous renal replacement therapies, which may prolong circuit lifetime and decrease hemorrhagic complications.
A retrospective comparative cohort study based on a prospective observational registry was conducted including critically ill children undergoing CRRT.
Efficacy, measured as circuit survival, and secondary effects of heparin and citrate were compared.
12 patients on CRRT with citrate anticoagulation and 24 patients with heparin anticoagulation were analyzed.
Median citrate dose was 2.6 mmol/L.
Median calcium dose was 0.16 mEq/kg/h.
Median heparin dose was 15 UI/kg/h.
Median circuit survival was 48 hours with citrate and 31 hours with heparin (P=0.028).
66.6% of patients treated with citrate developed mild metabolic alkalosis, which was directly related to citrate dose.
There were no cases of citrate intoxication: median total calcium/ionic calcium index (CaT/I) of 2.16 and a maximum CaT/I of 2.33, without metabolic acidosis.
In the citrate group, 45.5% of patients developed hypochloremia and 27.3% hypomagnesemia.
In the heparin group, 27.8% developed hypophosphatemia.
Three patients were moved from heparin to citrate to control postoperatory bleeding.
In conclusion citrate is a safe and effective anticoagulation method for CRRT in children and it achieves longer circuit survival than heparin.
American Psychological Association (APA)
Fernández, Sara Nicole& Santiago, Maria José& López-Herce, Jesús& García, Miriam& Del Castillo, Jimena& Alcaraz, Andrés José…[et al.]. 2014. Citrate Anticoagulation for CRRT in Children : Comparison with Heparin. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-497992
Modern Language Association (MLA)
Fernández, Sara Nicole…[et al.]. Citrate Anticoagulation for CRRT in Children : Comparison with Heparin. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-497992
American Medical Association (AMA)
Fernández, Sara Nicole& Santiago, Maria José& López-Herce, Jesús& García, Miriam& Del Castillo, Jimena& Alcaraz, Andrés José…[et al.]. Citrate Anticoagulation for CRRT in Children : Comparison with Heparin. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-497992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-497992