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The Copper Radioisotopes : A Systematic Review with Special Interest to 64Cu
Joint Authors
Altini, Corinna
Notaristefano, Antonio
Niccoli Asabella, Artor
Rubini, Giuseppe
Paparella, Domenico
Cascini, Giuseppe Lucio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Copper (Cu) is an important trace element in humans; it plays a role as a cofactor for numerous enzymes and other proteins crucial for respiration, iron transport, metabolism, cell growth, and hemostasis.
Natural copper comprises two stable isotopes, 63Cu and 65Cu, and 5 principal radioisotopes for molecular imaging applications (60Cu, 61Cu, 62Cu, and 64Cu) and in vivo targeted radiation therapy (64Cu and 67Cu).
The two potential ways to produce Cu radioisotopes concern the use of the cyclotron or the reactor.
A noncopper target is used to produce noncarrier-added Cu thanks to a chemical separation from the target material using ion exchange chromatography achieving a high amount of radioactivity with the lowest possible amount of nonradioactive isotopes.
In recent years, Cu isotopes have been linked to antibodies, proteins, peptides, and nanoparticles for preclinical and clinical research; pathological conditions that influence Cu metabolism such as Menkes syndrome, Wilson disease, inflammation, tumor growth, metastasis, angiogenesis, and drug resistance have been studied.
We aim to discuss all Cu radioisotopes application focusing on 64Cu and in particular its form 64CuCl2 that seems to be the most promising for its half-life, radiation emissions, and stability with chelators, allowing several applications in oncological and nononcological fields.
American Psychological Association (APA)
Niccoli Asabella, Artor& Cascini, Giuseppe Lucio& Altini, Corinna& Paparella, Domenico& Notaristefano, Antonio& Rubini, Giuseppe. 2014. The Copper Radioisotopes : A Systematic Review with Special Interest to 64Cu. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-498013
Modern Language Association (MLA)
Niccoli Asabella, Artor…[et al.]. The Copper Radioisotopes : A Systematic Review with Special Interest to 64Cu. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-498013
American Medical Association (AMA)
Niccoli Asabella, Artor& Cascini, Giuseppe Lucio& Altini, Corinna& Paparella, Domenico& Notaristefano, Antonio& Rubini, Giuseppe. The Copper Radioisotopes : A Systematic Review with Special Interest to 64Cu. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-498013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498013