Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis
Joint Authors
Gross, Wolfgang L.
Knaup, Silvia
Epplen, Jörg T.
Wieczorek, Stefan
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-02-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
A major genomic region involved in Wegener's granulomatosis includes the gene for retinoid receptor beta (RXRB) which forms heterodimers with peroxisome proliferator-activated receptors (PPARs).
It is unclear whether this association directly arises from the RXRB allele(s) or via a linked variation.
In order to reveal any hitherto unknown and potentially disease-relevant variation of the RXRB gene, we have genotyped four tagging SNPs of this genomic region and have directly sequenced selected WG patients and controls representing disease-associated haplotypes.
Additionally, we have genotyped 2 SNPs each in the genes for PPARα and PPARγ (PPARA and PPARG).
Hence, we confirmed the strong association of the RXRB locus with WG but could not reveal any novel variation in RXRB.
None of the PPARA and PPARG SNPs showed association with WG.
Moreover, no epistatic effect was seen between RXRB and PPARA/PPARG alleles.
These results do not support an etiopathological role of PPAR in WG.
Analyses of further genes functionally linked to RXRB may provide additional data useful to evaluate the RXRB association found in WG.
American Psychological Association (APA)
Wieczorek, Stefan& Knaup, Silvia& Gross, Wolfgang L.& Epplen, Jörg T.. 2009. Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis. PPAR Research،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-498038
Modern Language Association (MLA)
Wieczorek, Stefan…[et al.]. Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis. PPAR Research No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-498038
American Medical Association (AMA)
Wieczorek, Stefan& Knaup, Silvia& Gross, Wolfgang L.& Epplen, Jörg T.. Genetic Variability of RXRB, PPARA, and PPARG in Wegener's Granulomatosis. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-498038
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498038