Scopoletin Inhibits Rat Aldose Reductase Activity and Cataractogenesis in Galactose-Fed Rats
Joint Authors
Kim, Chan-Sik
Lee, Yun Mi
Jo, Kyuhyung
Shin, So Dam
Sohn, Eunjin
Kim, Junghyun
Kim, Jin Sook
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cataracts are a major cause of human blindness.
Aldose reductase (AR) is an important rate-limiting enzyme that contributes to cataract induction in diabetic patients.
Scopoletin is the main bioactive constituent of flower buds from Magnolia fargesii and is known to inhibit AR activity.
To assess scopoletin’s ability to mitigate sugar cataract formation in vivo, we studied its effects in a rat model of dietary galactose-induced sugar cataracts.
Galactose-fed rats were orally dosed with scopoletin (10 or 50 mg/kg body weight) once a day for 2 weeks.
Administering scopoletin delayed the progression of the cataracts that were induced by dietary galactose.
Scopoletin also prevented galactose-induced changes in lens morphology, such as lens fiber swelling and membrane rupture.
Scopoletin’s protective effect against sugar cataracts was mediated by inhibiting both AR activity and oxidative stress.
These results suggest that scopoletin is a useful treatment for sugar cataracts.
American Psychological Association (APA)
Kim, Junghyun& Kim, Chan-Sik& Lee, Yun Mi& Sohn, Eunjin& Jo, Kyuhyung& Shin, So Dam…[et al.]. 2013. Scopoletin Inhibits Rat Aldose Reductase Activity and Cataractogenesis in Galactose-Fed Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-498072
Modern Language Association (MLA)
Kim, Junghyun…[et al.]. Scopoletin Inhibits Rat Aldose Reductase Activity and Cataractogenesis in Galactose-Fed Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-498072
American Medical Association (AMA)
Kim, Junghyun& Kim, Chan-Sik& Lee, Yun Mi& Sohn, Eunjin& Jo, Kyuhyung& Shin, So Dam…[et al.]. Scopoletin Inhibits Rat Aldose Reductase Activity and Cataractogenesis in Galactose-Fed Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-498072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498072