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Innovative Therapies against Human Glioblastoma Multiforme
Joint Authors
Cimini, Annamaria
Ippoliti, Rodolfo
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Glioblastoma multiforme is the most invasive and aggressive brain tumor in humans, and despite the latest chemical and radiative therapeutic approaches, it is still scarcely sensitive to these treatments and is generally considered an incurable disease.
This paper will focus on the latest approaches to the treatment of this cancer, including the new chemicals such as proautophagic drugs and kinases inhibitors, and differentiating agents.
In this field, there have been opening new perspectives as the discovery of possible specific targets such as the EGFRvIII, a truncated form of the EGF receptor.
Antibodies against these targets can be used as proapoptotic agents and as possible carriers for chemicals, drugs, radioisotopes, and toxins.
In this paper, we review the possible mechanism of action of these therapies, with particular attention to the combined use of toxic substances (for example, immunotoxins) and antiproliferative/differentiating compounds (i.e., ATRA, PPARγ agonists).
All these aspects will be discussed in the view of progress clinical trials and of possible new approaches for directed drug formulations.
American Psychological Association (APA)
Cimini, Annamaria& Ippoliti, Rodolfo. 2011. Innovative Therapies against Human Glioblastoma Multiforme. ISRN Oncology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-498104
Modern Language Association (MLA)
Cimini, Annamaria& Ippoliti, Rodolfo. Innovative Therapies against Human Glioblastoma Multiforme. ISRN Oncology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-498104
American Medical Association (AMA)
Cimini, Annamaria& Ippoliti, Rodolfo. Innovative Therapies against Human Glioblastoma Multiforme. ISRN Oncology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-498104
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498104