Plasma Exchange in Severe Attacks of Neuromyelitis Optica
Joint Authors
Bonnan, Mickael
Cabre, Philippe
Source
Multiple Sclerosis International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Neuromyelitis optica (NMO) attacks are poorly controlled by steroids and evolve in stepwise neurological impairments.
Assuming the strong humoral response underlying NMO attacks, plasma exchange (PLEX) is an appropriate technique in severe NMO attacks.
Objective.
Presenting an up-to-date review of the literature of PLEX in NMO.
Methods.
We summarize the rationale of PLEX in relation with the physiology of NMO, the main technical aspects, and the available studies.
Results.
PLEX in severe attacks from myelitis or optic neuritis are associated with a better outcome, depending on PLEX delay (“time is cord and eyes”).
NMO-IgG status has no influence.
Finally, we build up an original concept linking the inner dynamic of the lesion, the timing of PLEX onset and the expected clinical results.
Conclusion.
PLEX is a safe and efficient add-on therapy in NMO, in synergy with steroids.
Large therapeutic trials are required to definitely assess the procedure and define the time opportunity window.
American Psychological Association (APA)
Bonnan, Mickael& Cabre, Philippe. 2012. Plasma Exchange in Severe Attacks of Neuromyelitis Optica. Multiple Sclerosis International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-498113
Modern Language Association (MLA)
Bonnan, Mickael& Cabre, Philippe. Plasma Exchange in Severe Attacks of Neuromyelitis Optica. Multiple Sclerosis International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-498113
American Medical Association (AMA)
Bonnan, Mickael& Cabre, Philippe. Plasma Exchange in Severe Attacks of Neuromyelitis Optica. Multiple Sclerosis International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-498113
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498113