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The Mitochondrial Aminoacyl tRNA Synthetases : Genes and Syndromes
Joint Authors
Tiranti, Valeria
Ghezzi, Daniele
Diodato, Daria
Source
International Journal of Cell Biology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mitochondrial respiratory chain (RC) disorders are a group of genetically and clinically heterogeneous diseases.
This is because protein components of the RC are encoded by both mitochondrial and nuclear genomes and are essential in all cells.
In addition, the biogenesis and maintenance of mitochondria, including mitochondrial DNA (mtDNA) replication, transcription, and translation, require nuclear-encoded genes.
In the past decade, a growing number of syndromes associated with dysfunction of mtDNA translation have been reported.
This paper reviews the current knowledge of mutations affecting mitochondrial aminoacyl tRNAs synthetases and their role in the pathogenic mechanisms underlying the different clinical presentations.
American Psychological Association (APA)
Diodato, Daria& Ghezzi, Daniele& Tiranti, Valeria. 2014. The Mitochondrial Aminoacyl tRNA Synthetases : Genes and Syndromes. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-498131
Modern Language Association (MLA)
Diodato, Daria…[et al.]. The Mitochondrial Aminoacyl tRNA Synthetases : Genes and Syndromes. International Journal of Cell Biology No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-498131
American Medical Association (AMA)
Diodato, Daria& Ghezzi, Daniele& Tiranti, Valeria. The Mitochondrial Aminoacyl tRNA Synthetases : Genes and Syndromes. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-498131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498131