NCR-PCOPGene : An Exploratory Tool for Analysis of Sample-Classes Effect on Gene-Expression Relationships
Joint Authors
Querol, Enrique
Cedano, Juan
Huerta, Mario
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Background.
Microarray technology is so expensive and powerful that it is essential to extract maximum value from microarray data.
Our tools allow researchers to test and formulate from a hypothesis to entire models.
Results.
The objective of the NCRPCOPGene is to study the relationships among gene expressions under different conditions, to classify these conditions, and to study their effect on the different relationships.
The web application makes it easier to define the sample classes, grouping the microarray experiments either by using (a) biological, statistical, or any other previous knowledge or (b) their effect on the expression relationship maintained among specific genes of interest.
By means of the type (a) class definition, the researcher can add biological information to the gene-expression relationships.
The type (b) class definition allows for linking genes correlated neither linearly nor nonlinearly.
Conclusions.
The PCOPGene tools are especially suitable for microarrays with large sample series.
This application helps to identify cellular states and the genes involved in it in a flexible way.
The application takes advantage of the ability of our system to relate gene expressions; even when these relationships are noncontinuous and cannot be found using linear or nonlinear analytical methods.
American Psychological Association (APA)
Cedano, Juan& Huerta, Mario& Querol, Enrique. 2008. NCR-PCOPGene : An Exploratory Tool for Analysis of Sample-Classes Effect on Gene-Expression Relationships. Advances in Bioinformatics،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-498137
Modern Language Association (MLA)
Cedano, Juan…[et al.]. NCR-PCOPGene : An Exploratory Tool for Analysis of Sample-Classes Effect on Gene-Expression Relationships. Advances in Bioinformatics No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-498137
American Medical Association (AMA)
Cedano, Juan& Huerta, Mario& Querol, Enrique. NCR-PCOPGene : An Exploratory Tool for Analysis of Sample-Classes Effect on Gene-Expression Relationships. Advances in Bioinformatics. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-498137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498137