A Novel Membrane Protein-Specific SerineThreonine Kinase : Tissue Distribution and Role in Sperm Maturation
Joint Authors
Nath, Debjani
Bhattacharyya, Debdas
Bhoumik, Arpita
Dungdung, Sandhya R.
Das, Sujoy
Majumder, Gopal C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Our recent studies have described for the first time the purification of an ectoprotein kinase to apparent homogeneity using caprine sperm as the model.
Purified ectokinase (CIK) is a novel membrane protein-specific kinase that phosphorylates serine and threonine residues of ectophosphoproteins.
This study, using ELISA based on ecto-CIK antibody demonstrates that ecto-CIK level is remarkably higher in the sperm membrane than in the cytosol.
The epididymal sperm maturational event as well as sperm vertical velocity is associated with a significant increase in the ecto-CIK level.
Ecto-CIK, the membrane protein-specific kinase, is also present in all the tissues tested and is predominantly localized in the cell membrane.
Ubiquitous localization of the novel kinase on the mammalian cell membrane suggests that the kinase may play pivotal role in gamete as well as somatic cell regulation by modulating membrane biology through serine/threonine phosphorylation of specific membrane proteins located in the ectodomains.
American Psychological Association (APA)
Nath, Debjani& Bhoumik, Arpita& Das, Sujoy& Bhattacharyya, Debdas& Dungdung, Sandhya R.& Majumder, Gopal C.. 2012. A Novel Membrane Protein-Specific SerineThreonine Kinase : Tissue Distribution and Role in Sperm Maturation. ISRN Urology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-498147
Modern Language Association (MLA)
Nath, Debjani…[et al.]. A Novel Membrane Protein-Specific SerineThreonine Kinase : Tissue Distribution and Role in Sperm Maturation. ISRN Urology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-498147
American Medical Association (AMA)
Nath, Debjani& Bhoumik, Arpita& Das, Sujoy& Bhattacharyya, Debdas& Dungdung, Sandhya R.& Majumder, Gopal C.. A Novel Membrane Protein-Specific SerineThreonine Kinase : Tissue Distribution and Role in Sperm Maturation. ISRN Urology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-498147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498147