IgG4-Related Fibrotic Diseases from an Immunological Perspective : Regulators out of Control?
Joint Authors
Aalberse, Rob C.
Rispens, Theo
Lighaam, Laura C.
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Patients with autoimmune pancreatitis have a striking polyclonal elevation of total IgG4 in serum.
This observation has been confirmed and extended to other fibrotic conditions (that are therefore called IgG4-related disease) but as yet remains unexplained.
The affected tissue contains many IgG4-producing plasma cells embedded in a fibrotic matrix originating from activated mesenchymal (stellate) cells.
We propose that the process results from an unusual interaction between two regulatory systems: the regulatory arm of the immune system (including Bregs) and the tissue repair regulatory components orchestrated by the activated stellate cell.
This interaction results in ongoing mutual activation, generating TGFbeta, IL10, and vitamin D.
This environment suppresses most immune reactions but stimulates the development of IgG4-producing plasma cells.
American Psychological Association (APA)
Lighaam, Laura C.& Aalberse, Rob C.& Rispens, Theo. 2012. IgG4-Related Fibrotic Diseases from an Immunological Perspective : Regulators out of Control?. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-498159
Modern Language Association (MLA)
Lighaam, Laura C.…[et al.]. IgG4-Related Fibrotic Diseases from an Immunological Perspective : Regulators out of Control?. International Journal of Rheumatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-498159
American Medical Association (AMA)
Lighaam, Laura C.& Aalberse, Rob C.& Rispens, Theo. IgG4-Related Fibrotic Diseases from an Immunological Perspective : Regulators out of Control?. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-498159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498159