Pathogenic Mechanisms and In Vitro Diagnosis of AERD

Joint Authors

Maune, Steffen
Schäfer, Dirk

Source

Journal of Allergy

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-05-10

Country of Publication

Egypt

No. of Pages

18

Main Subjects

Medicine

Abstract EN

Aspirin-exacerbated respiratory disease (AERD) refers to chronic rhinosinusitis, nasal polyposis, bronchoconstriction, and/or eosinophilic inflammation in asthmatics following the exposure to nonsteroidal anti-inflammatory drugs (NSAIDs).

A key pathogenic mechanism associated with AERD is the imbalance of eicosanoid metabolism focusing on prostanoid and leukotriene pathways in airway mucosa as well as blood cells.

Genetic and functional metabolic studies on vital and non-vital cells pointed to the variability and the crucial role of lipid mediators in disease susceptibility and their response to medication.

Eicosanoids, exemplified by prostaglandin E2 (PGE2) and peptidoleukotrienes (pLT), are potential metabolic biomarkers contributing to the AERD phenotype.

Also other mediators are implicated in the progress of AERD.

Considering the various pathogenic mechanisms of AERD, a multitude of metabolic and genetic markers is suggested to be implicated and were introduced as potential biomarkers for in vitro diagnosis during the past decades.

Deduced from an eicosanoid-related pathogenic mechanism, functional tests balancing PGE2 and pLT as well as other eicosanoids from preferentially vital leukocytes demonstrated their applicability for in vitro diagnosis of AERD.

American Psychological Association (APA)

Schäfer, Dirk& Maune, Steffen. 2012. Pathogenic Mechanisms and In Vitro Diagnosis of AERD. Journal of Allergy،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-498166

Modern Language Association (MLA)

Schäfer, Dirk& Maune, Steffen. Pathogenic Mechanisms and In Vitro Diagnosis of AERD. Journal of Allergy No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-498166

American Medical Association (AMA)

Schäfer, Dirk& Maune, Steffen. Pathogenic Mechanisms and In Vitro Diagnosis of AERD. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-498166

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-498166