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Chimonanthus nitens var. salicifolius Aqueous Extract Protects against 5-Fluorouracil Induced Gastrointestinal Mucositis in a Mouse Model
Joint Authors
Wang, Weigang
Wang, Zhugang
Xi, Jun
Schroeder, Sven
Xie, Tianpei
Fei, Jian
Liu, Zhenze
Bao, Shisan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Gastrointestinal mucositis is a major side effect of chemotherapy, leading to life quality reduction in patients and interrupting the therapy of cancer.
Chimonanthus nitens var.
salicifolius (CS) is a traditional Chinese herb for enteral disease.
Considering the protective effect of CS on intestine, we hypothesize that the aqueous extract of CS could be benefcial to gastrointestinal mucositis.
To verify this, a mouse mucositis model was induced by 5-Fluorouracil (5-Fu).
Male Balb/C mice were treated with CS aqueous extract (5, 10, and 20 g/kg) or loperamide (0.2 mg/kg) intragastrically for 11 days, and the severity of mucositis was evaluated.
Furthermore, the chemical compounds of CS aqueous extract were also analysed by high-performance liquid chromatography (HPLC).
Our results demonstrated that CS aqueous extract improved mice body weight, diarrhoea, and faecal blood, maintained the liver function and intestinal length, alleviated villus shortening, and suppressed the apoptosis and inflammation in small intestine.
We concluded that CS could protect mice against 5-Fu induced mucositis by inhibiting apoptosis and inflammation, and this protective effect might be associated with the 3 flavonoids (rutin, quercetin, and kaempferol) identified in CS aqueous extract.
American Psychological Association (APA)
Liu, Zhenze& Xi, Jun& Schroeder, Sven& Wang, Weigang& Xie, Tianpei& Wang, Zhugang…[et al.]. 2013. Chimonanthus nitens var. salicifolius Aqueous Extract Protects against 5-Fluorouracil Induced Gastrointestinal Mucositis in a Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-498169
Modern Language Association (MLA)
Liu, Zhenze…[et al.]. Chimonanthus nitens var. salicifolius Aqueous Extract Protects against 5-Fluorouracil Induced Gastrointestinal Mucositis in a Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-498169
American Medical Association (AMA)
Liu, Zhenze& Xi, Jun& Schroeder, Sven& Wang, Weigang& Xie, Tianpei& Wang, Zhugang…[et al.]. Chimonanthus nitens var. salicifolius Aqueous Extract Protects against 5-Fluorouracil Induced Gastrointestinal Mucositis in a Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-498169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498169