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Neuroendocrine Differentiation Is a Prognostic Factor for Stage II Poorly Differentiated Colorectal Cancer
Joint Authors
Wang, Xiaowei
Yi, Chenghao
Hu, Lifeng
Tong, Zhou
Ding, Kefeng
Xiao, Qian
Jiao, Yurong
Liu, Yue
Li, Jun
Hu, Yeting
Li, Qiong
Xu, Jinghong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Neuroendocrine differentiation (NED) in colorectal cancer is an indistinct phenomenon and may define a new cancer subtype, especially in the poorly differentiated colorectal cancer (PDCRC).
The clinical features of PDCRC with NED remain controversial, thus confusing the implementation of individualized treatment.
This study included 171 patients who underwent surgery from 2000 to 2011 and had pathology-confirmed PDCRC.
Each sample was examined by immunohistochemistry for the biological markers of NED, synaptophysin (Syn), and chromogranin (CgA).
Patients with Syn(+) and/or CgA(+) cells were classified as NED(+); otherwise, they were NED(−).
Data were collected for patients who were followed up for at least two years.
NED(+) staining was present in 71 (41.5%) patients.
The median survival time was 36.9 months.
No survival differences existed between the NED(−) and NED(+) groups (P>0.05).
However, stage II NED(+) patients had a significantly worse prognosis than NED(−) patients (P=0.018).
For the NED(+) group, the median survival was 38.56 months, and the 5-year survival was 65%.
For the NED(−) group, the median survival was 53.18 months, and the 5-year survival was 90%.
NED is a common event in primary PDCRC.
For stage II PDCRC, NED(+) indicates a poor prognosis.
American Psychological Association (APA)
Liu, Yue& Xu, Jinghong& Jiao, Yurong& Hu, Yeting& Yi, Chenghao& Li, Qiong…[et al.]. 2014. Neuroendocrine Differentiation Is a Prognostic Factor for Stage II Poorly Differentiated Colorectal Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-498216
Modern Language Association (MLA)
Liu, Yue…[et al.]. Neuroendocrine Differentiation Is a Prognostic Factor for Stage II Poorly Differentiated Colorectal Cancer. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-498216
American Medical Association (AMA)
Liu, Yue& Xu, Jinghong& Jiao, Yurong& Hu, Yeting& Yi, Chenghao& Li, Qiong…[et al.]. Neuroendocrine Differentiation Is a Prognostic Factor for Stage II Poorly Differentiated Colorectal Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-498216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498216