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Langerhans Cell Histiocytosis of the Cranial Base : Is Low-Dose Radiotherapy Effective?
Joint Authors
Stark, Michael
Christiansen, Hans
Meyer, Andreas
Bruns, Frank
Karstens, Johann H.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-16
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Introduction.
Langerhans cell histiocytosis (LCH) is a rare disease of unknown etiology with different clinical features.
A standardised treatment has not been established so far.
Case Report.
We report a case of a 28-year-old patient who initially presented with hypesthesia of the fifth cranial nerve and pain of the left ear.
Diagnosis showed a tumour localised in the cranial base with a maximum diameter of 4.1 cm.
The diagnosis of LCH was confirmed histologically by biopsy.
Diagnostic workup verified the cranial lesion as the sole manifestation of LCH.
A total dose of 9 Gy (single dose 1.8 Gy) was delivered.
The symptoms dissolved completely within 6 months after radiation; repeated CT and MRI scans revealed a reduction in size of the lesion and a remineralisation of the bone.
After a followup of 13 years the patient remains free of symptoms without relapse or any side effects from therapy.
Discussion.
Due to the indolent course of the disease with a high rate of spontaneous remissions the choice of treatment strongly depends on the individual clinical situation.
In the presented case low-dose radiotherapy was sufficient to obtain long-term local control in a region with critical structures and tissues.
American Psychological Association (APA)
Meyer, Andreas& Stark, Michael& Karstens, Johann H.& Christiansen, Hans& Bruns, Frank. 2012. Langerhans Cell Histiocytosis of the Cranial Base : Is Low-Dose Radiotherapy Effective?. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-498225
Modern Language Association (MLA)
Meyer, Andreas…[et al.]. Langerhans Cell Histiocytosis of the Cranial Base : Is Low-Dose Radiotherapy Effective?. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-498225
American Medical Association (AMA)
Meyer, Andreas& Stark, Michael& Karstens, Johann H.& Christiansen, Hans& Bruns, Frank. Langerhans Cell Histiocytosis of the Cranial Base : Is Low-Dose Radiotherapy Effective?. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-498225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498225