Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre
Joint Authors
Vannasiri, Supaporn
Nanna, Urarat
Sireeratawong, Seewaboon
Jaijoy, Kanjana
Singhalak, Tipaya
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
We studied an acute and chronic oral toxicity of the extract from Ziziphus attopensis (ZA) in male and female SD rats according to the OECD guidelines.
After a single oral administration of ZA 5 g/kg body weight, measurement of the body and organs, necropsy, and health monitoring were performed.
The body and organ weights and behavior were not changed relative to the control rats indicating that ZA does not produce acute toxicity.
The chronic toxicity was determined by oral feeding both male and female rats daily with ZA at the doses of 1, 2, 4, and 8 g/kg body weight for 180 days.
Body weight changes, hematological and biochemical parameters, organ weights, gross finding, and histopathology examination were monitored during the experimental period.
The results did not show any differences from the control groups.
Analyses of these results with the information of signs, behavior, and health monitoring can lead to a conclusion that the long-term oral administration of ZA for 180 days does not cause chronic toxicity.
American Psychological Association (APA)
Sireeratawong, Seewaboon& Vannasiri, Supaporn& Nanna, Urarat& Singhalak, Tipaya& Jaijoy, Kanjana. 2012. Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-498226
Modern Language Association (MLA)
Sireeratawong, Seewaboon…[et al.]. Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre. ISRN Pharmacology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-498226
American Medical Association (AMA)
Sireeratawong, Seewaboon& Vannasiri, Supaporn& Nanna, Urarat& Singhalak, Tipaya& Jaijoy, Kanjana. Evaluation of Acute and Chronic Toxicities of the Water Extract from Ziziphus attopensis Pierre. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-498226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498226