Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma : A Longitudinal Analysis
Joint Authors
Beyene, Joseph
Allen, Alexander C.
To, Teresa
Mustard, Cameron A.
Pole, Jason D.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study was designed to test the hypothesis that fetal exposure to corticosteroids in the antenatal period is an independent risk factor for the development of asthma in early childhood with little or no effect in later childhood.
A population-based cohort study of all pregnant women who resided in Nova Scotia, Canada, and gave birth to a singleton fetus between 1989 and 1998 was undertaken.
After a priori specified exclusions, 80,448 infants were available for analysis.
Using linked health care utilization records, incident asthma cases developed after 36 months of age were identified.
Extended Cox proportional hazards models were used to estimate hazard ratios while controlling for confounders.
Exposure to corticosteroids during pregnancy was associated with a risk of asthma in childhood between 3–5 years of age: adjusted hazard ratio of 1.19 (95% confidence interval: 1.03, 1.39), with no association noted after 5 years of age: adjusted hazard ratio for 5–7 years was 1.06 (95% confidence interval: 0.86, 1.30) and for 8 or greater years was 0.74 (95% confidence interval: 0.54, 1.03).
Antenatal steroid therapy appears to be an independent risk factor for the development of asthma between 3 and 5 years of age.
American Psychological Association (APA)
Pole, Jason D.& Mustard, Cameron A.& To, Teresa& Beyene, Joseph& Allen, Alexander C.. 2010. Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma : A Longitudinal Analysis. Journal of Pregnancy،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-498238
Modern Language Association (MLA)
Pole, Jason D.…[et al.]. Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma : A Longitudinal Analysis. Journal of Pregnancy No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-498238
American Medical Association (AMA)
Pole, Jason D.& Mustard, Cameron A.& To, Teresa& Beyene, Joseph& Allen, Alexander C.. Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma : A Longitudinal Analysis. Journal of Pregnancy. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-498238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498238