Soluplus Graft Copolymer : Potential Novel Carrier Polymer in Electrospinning of Nanofibrous Drug Delivery Systems for Wound Therapy
Joint Authors
Lust, Andres
Paaver, Urve
Heinämäki, Jyrki
Kogermann, Karin
Tamm, Ingrid
Kirsimäe, Kalle
Veski, Peep
Laidmäe, Ivo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Electrospinning is an effective method in preparing polymeric nanofibrous drug delivery systems (DDSs) for topical wound healing and skin burn therapy applications.
The aim of the present study was to investigate a new synthetic graft copolymer (Soluplus) as a hydrophilic carrier polymer in electrospinning of nanofibrous DDSs.
Soluplus (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PCL-PVAc-PEG)) was applied in the nonwoven nanomats loaded with piroxicam (PRX) as a poorly water-soluble drug.
Raman spectroscopy, X-ray powder diffraction, differential scanning calorimetry, and scanning electron microscopy (SEM) were used in the physical characterization of nanofibrous DDSs.
According to the SEM results, the drug-loaded PCL-PVAc-PEG nanofibers were circular in cross-section with an average diameter ranging from 500 nm up to 2 µm.
Electrospinning stabilized the amorphous state of PRX.
In addition, consistent and sustained-release profile was achieved with the present nanofibrous DDSs at the physiologically relevant temperature and pH applicable in wound healing therapy.
In conclusion, electrospinning can be used to prepare nanofibrous DDSs of PCL-PVAc-PEG graft copolymer (Soluplus) and to stabilize the amorphous state of a poorly water-soluble PRX.
The use of this synthetic graft copolymer can open new options to formulate nanofibrous DDSs for wound healing.
American Psychological Association (APA)
Paaver, Urve& Tamm, Ingrid& Laidmäe, Ivo& Lust, Andres& Kirsimäe, Kalle& Veski, Peep…[et al.]. 2014. Soluplus Graft Copolymer : Potential Novel Carrier Polymer in Electrospinning of Nanofibrous Drug Delivery Systems for Wound Therapy. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-498242
Modern Language Association (MLA)
Paaver, Urve…[et al.]. Soluplus Graft Copolymer : Potential Novel Carrier Polymer in Electrospinning of Nanofibrous Drug Delivery Systems for Wound Therapy. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-498242
American Medical Association (AMA)
Paaver, Urve& Tamm, Ingrid& Laidmäe, Ivo& Lust, Andres& Kirsimäe, Kalle& Veski, Peep…[et al.]. Soluplus Graft Copolymer : Potential Novel Carrier Polymer in Electrospinning of Nanofibrous Drug Delivery Systems for Wound Therapy. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-498242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498242