Oxidative Stress Markers in Prostate Cancer Patients after HDR Brachytherapy Combined with External Beam Radiation
Joint Authors
Masiak, Rafał
Woźniak, Alina
Makarewicz, Roman
Szpinda, Michał
Mila-Kierzenkowska, Celestyna
Szpinda, Anna
Woźniak, Bartosz
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Assessment of oxidative stress markers was perfomed in prostate cancer (PCa) patients subjected to high-dose brachytherapy (HDR) with external beam radiotherapy (EBRT).
Sixty men with PCa were subjected to combined two-fraction treatment with HDR (tot.
20 Gy) and EBRT (46 Gy).
Blood samples were taken before treatment, immediately afterwards, after 1.5–3 months, and approx.
2 years.
Control group consisted of 30 healthy men.
Erythrocyte glutathione peroxidase activity in the patients was lower than in healthy subjects by 34% (P<0.001), 50% (P<0.001), 30% (P<0.05), and 61% (P<0.001), respectively, at all periods.
No significant differences were found by comparing superoxide dismutase and catalase activity in PCa patients with that of the controls.
After 2 years of the end of treatment, the activity of studied enzymes demonstrated a decreasing tendency versus before therapy.
Blood plasma thiobarbituric acid reactive substances (TBARS) concentration was higher than in the controls at all periods, while erythrocyte TBARS decreased after 2 years to control levels.
The results confirm that in the course of PCa, imbalance of oxidant-antioxidant processes occurs.
The therapy did not alter the levels of oxidative stress markers, which may prove its applicability.
Two years is too short a period to restore the oxidant-antioxidant balance.
American Psychological Association (APA)
Woźniak, Alina& Masiak, Rafał& Szpinda, Michał& Mila-Kierzenkowska, Celestyna& Woźniak, Bartosz& Makarewicz, Roman…[et al.]. 2012. Oxidative Stress Markers in Prostate Cancer Patients after HDR Brachytherapy Combined with External Beam Radiation. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-498250
Modern Language Association (MLA)
Woźniak, Alina…[et al.]. Oxidative Stress Markers in Prostate Cancer Patients after HDR Brachytherapy Combined with External Beam Radiation. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-498250
American Medical Association (AMA)
Woźniak, Alina& Masiak, Rafał& Szpinda, Michał& Mila-Kierzenkowska, Celestyna& Woźniak, Bartosz& Makarewicz, Roman…[et al.]. Oxidative Stress Markers in Prostate Cancer Patients after HDR Brachytherapy Combined with External Beam Radiation. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-498250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498250