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Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation
Joint Authors
Seitz, Gabriele
Kanz, Lothar
Bautz, Frank
Yildirim, Sedat
Möhle, Robert
Weisel, Katja C.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In mice, differential regulation of CXC chemokine receptor expression in circulating polymorphonuclear neutrophils (PMNs) undergoing senescence results in homing to the bone marrow.
However, the role of this compartment and of the chemokine receptor CXCR4 is still under discussion, and only scarce data exist about CXCR4 function in human PMN.
In our study, we provide evidence that also in human neutrophils, expression (cell surface and mRNA), chemotactic and signaling functions of the homing-related chemokine receptor CXCR4 are upregulated during aging in vitro, independent of addition of stimulatory cytokines (TNF, IL-1, IL-8, G-CSF).
In contrast, interleukin-8 receptors are downmodulated (CXCR2) or remain unchanged (CXCR1), suggesting that human PMNs undergoing senescence acquire a phenotype that impairs inflammatory extravasation and favors homing to the bone marrow or other tissues involved in sequestration.
Partially retained responsiveness to interleukin-8 may be important for neutrophil function when senescence occurs after extravasation in inflamed tissues.
American Psychological Association (APA)
Weisel, Katja C.& Bautz, Frank& Seitz, Gabriele& Yildirim, Sedat& Kanz, Lothar& Möhle, Robert. 2009. Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-498261
Modern Language Association (MLA)
Weisel, Katja C.…[et al.]. Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation. Mediators of Inflammation No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-498261
American Medical Association (AMA)
Weisel, Katja C.& Bautz, Frank& Seitz, Gabriele& Yildirim, Sedat& Kanz, Lothar& Möhle, Robert. Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-498261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498261