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Exogenous Control of the Expression of Group I CD1 Molecules Competent for Presentation of Microbial Nonpeptide Antigens to Human T Lymphocytes
Joint Authors
Aquino, Angelo
Graziani, Grazia
Franzese, Ornella
Prete, Salvatore P.
Bonmassar, Enzo
Bonmassar, Laura
D'Atri, Stefania
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-22
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Group I CD1 (CD1a, CD1b, and CD1c) glycoproteins expressed on immature and mature dendritic cells present nonpeptide antigens (i.e., lipid or glycolipid molecules mainly of microbial origin) to T cells.
Cytotoxic CD1-restricted T lymphocytes recognizing mycobacterial lipid antigens were found in tuberculosis patients.
However, thanks to a complex interplay between mycobacteria and CD1 system, M.
tuberculosis possesses a successful tactic based, at least in part, on CD1 downregulation to evade CD1-dependent immunity.
On the ground of these findings, it is reasonable to hypothesize that modulation of CD1 protein expression by chemical, biological, or infectious agents could influence host's immune reactivity against M.
tuberculosis-associated lipids, possibly affecting antitubercular resistance.
This scenario prompted us to perform a detailed analysis of the literature concerning the effect of external agents on Group I CD1 expression in order to obtain valuable information on the possible strategies to be adopted for driving properly CD1-dependent immune functions in human pathology and in particular, in human tuberculosis.
American Psychological Association (APA)
Aquino, Angelo& Graziani, Grazia& Franzese, Ornella& Prete, Salvatore P.& Bonmassar, Enzo& Bonmassar, Laura…[et al.]. 2011. Exogenous Control of the Expression of Group I CD1 Molecules Competent for Presentation of Microbial Nonpeptide Antigens to Human T Lymphocytes. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-27.
https://search.emarefa.net/detail/BIM-498292
Modern Language Association (MLA)
Aquino, Angelo…[et al.]. Exogenous Control of the Expression of Group I CD1 Molecules Competent for Presentation of Microbial Nonpeptide Antigens to Human T Lymphocytes. Clinical and Developmental Immunology No. 2011 (2011), pp.1-27.
https://search.emarefa.net/detail/BIM-498292
American Medical Association (AMA)
Aquino, Angelo& Graziani, Grazia& Franzese, Ornella& Prete, Salvatore P.& Bonmassar, Enzo& Bonmassar, Laura…[et al.]. Exogenous Control of the Expression of Group I CD1 Molecules Competent for Presentation of Microbial Nonpeptide Antigens to Human T Lymphocytes. Clinical and Developmental Immunology. 2011. Vol. 2011, no. 2011, pp.1-27.
https://search.emarefa.net/detail/BIM-498292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498292