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Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction
Joint Authors
Papassotiriou, Ioannis
Kanaka-Gantenbein, Christina
Kyriakakou, Marialena
Hassiakos, Demetrios
Malamitsi-Puchner, Ariadne
Boutsikou, Theodora
Margeli, Alexandra
Mastorakos, George
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We aimed to investigate possible alterations in circulating levels of the perinatal stress markers high sensitivity (hs)-CRP, PAI-1, and S100B—probably reflecting brain and adipose tissue inflammation—in intrauterine growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) pregnancies, given that these groups differ in fat mass and metabolic mechanisms involving aseptic inflammation.
Serum hs-CRP, PAI-1, and S100B levels were measured in 40 mothers, and their 20 AGA and 20 IUGR full-term fetuses and neonates on postnatal days 1 and 4.
hs-CRP, PAI-1, and S100B levels did not differ at all time points between AGA and IUGR groups.
We conclude that the lack of difference in hs-CRP, PAI-1 and S100B levels, between IUGR and AGA fetuses/neonates—despite the lower birth weight, reflecting reduced fat mass in the former—might indicate more intense adipose tissue and nervous system inflammation in IUGRs.
However, implication of other inflammation-related mechanisms, common in the IUGR state (e.g.
preeclampsia), cannot be excluded.
American Psychological Association (APA)
Boutsikou, Theodora& Mastorakos, George& Kyriakakou, Marialena& Margeli, Alexandra& Hassiakos, Demetrios& Papassotiriou, Ioannis…[et al.]. 2010. Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-498311
Modern Language Association (MLA)
Boutsikou, Theodora…[et al.]. Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-498311
American Medical Association (AMA)
Boutsikou, Theodora& Mastorakos, George& Kyriakakou, Marialena& Margeli, Alexandra& Hassiakos, Demetrios& Papassotiriou, Ioannis…[et al.]. Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-498311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498311