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Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature
Joint Authors
Kardar, M.
Sivaloganathan, Sivabal
Haselwandter, C. A.
Kohandel, Mohammad
Sengupta, S.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The combination of cytotoxic therapies and antiangiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors.
However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome.
Using a mathematical modeling approach that is grounded on available experimental data, we investigate the spatial and temporal targeting of tumor cells and neovasculature with a nanoscale delivery system.
Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue.
The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.
American Psychological Association (APA)
Kohandel, Mohammad& Haselwandter, C. A.& Kardar, M.& Sengupta, S.& Sivaloganathan, Sivabal. 2011. Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature. Computational and Mathematical Methods in Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-498327
Modern Language Association (MLA)
Kohandel, Mohammad…[et al.]. Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature. Computational and Mathematical Methods in Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-498327
American Medical Association (AMA)
Kohandel, Mohammad& Haselwandter, C. A.& Kardar, M.& Sengupta, S.& Sivaloganathan, Sivabal. Quantitative Model for Efficient Temporal Targeting of Tumor Cells and Neovasculature. Computational and Mathematical Methods in Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-498327
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498327