Silent Burdens in Disease : Fatigue and Depression in SLE
Joint Authors
Bernardes, Miguel
Terroso, G.
Figueiredo-Braga, M.
Fonseca, R.
de Sousa, Maria
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
At a time when health is being recognized as more than just avoiding death, age and comorbidity are becoming increasingly important aspects of chronic disease.
Systemic Lupus Erythematous (SLE) is probably one of the best paradigms of modern chronic disease, sitting at the crossroads of numerous somatic health problems, immune activation, depression, pain, and fatigue.
One hundred forty-eight female participants were enrolled in the present study: 50 diagnosed with SLE, 45 with major depressive disorder (MDD), and 53 age-matched controls.
Statistically significant lower scores in quality-of-life dimensions related to physical impairment were found in SLE.
Patients with MDD presented significant levels of pain, reduced physical summary component (PSC), and general health scores different from healthy controls.
Fatigue was reported in 90% of women with SLE and 77.8% of the MDD patients in contrast with 39.6% in the control group.
Significant correlations were seen among fatigue severity, age, and educational level in SLE.
From our own previous work and more recent work on the association of immune activation and depression, unexplained fatigue in SLE may signify an early sign of immune activation flare-up.
The search for cytokine markers should perhaps be extended to fatigue in SLE.
American Psychological Association (APA)
Fonseca, R.& Bernardes, Miguel& Terroso, G.& de Sousa, Maria& Figueiredo-Braga, M.. 2014. Silent Burdens in Disease : Fatigue and Depression in SLE. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-498328
Modern Language Association (MLA)
Fonseca, R.…[et al.]. Silent Burdens in Disease : Fatigue and Depression in SLE. Autoimmune Diseases No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-498328
American Medical Association (AMA)
Fonseca, R.& Bernardes, Miguel& Terroso, G.& de Sousa, Maria& Figueiredo-Braga, M.. Silent Burdens in Disease : Fatigue and Depression in SLE. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-498328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-498328